Undoubtedly, skilled and skilled manpower organizes the basis of a country's economic progress; Therefore, managing and guiding manpower and providing their physical and mental health is of great importance to achieving macroeconomic goals. In this regard, the present article is designed to identify and analyze jurisprudential rules on the need to provide human resources health in the light of the teachings of Islamic law and Quranic foundations. It is worth noting that the present study is of qualitative type and is in terms of the method of implementation. Reflection in the religious education system as well as the jurisprudential writings of Imamiyyah shows that the Shari'ah of Islam, while honoring the value of work and human resources, in its teachings, recognizes numerous and varied rights in terms of material and spiritual health for this class. Is. It seems that the rules of the health of the workforce can be identified in the following three macro-jurisprudential rules: 1- The Qur'anic rule of the inherent dignity of human beings to which the dignity of human resources in various aspects, including health care, must to be observed 2. The rule of negation, whose root can be identified in the Qur'anic teachings, must be remedied by any factor that endangers the health of the labor force. 3. The rule of rituals, which, according to the provisions of that employer, must handle the damages caused to the health of the human resources.