Dealing with religious and jurisprudential doubts has always been one of the major challenges in Islamic societies. In Shiite jurisprudence, to respond to these doubts, special jurisprudential and fundamental principles are used that are in line with the Quran, the Sunnah of the Infallibles (peace be upon them), and reason. In this regard, the principle of caution is used as one of the most important tools to prevent jurisprudential errors and doubts when dealing with issues whose religious ruling is not clear. The rule of innocence, as a fundamental principle in Shiite jurisprudence, from a rational and religious perspective, absolves a person from obligations in cases where there is doubt. The rule of non-harm, especially in response to new doubts, means that no ruling should lead to unbearable harm. Along with these principles, the use of reason as a jurisprudential source plays a fundamental role in understanding and explaining religious issues. In addition, dynamic ijtihad in Shiite jurisprudence is effective as a new approach in responding to doubts in new conditions and adapting jurisprudential issues to the developments of time and place. On the other hand, scientific dialogue and interaction are among the main teachings of the Quran and the life of the infallibles (peace be upon them), based on which scientific debates and discussions are presented as an effective tool in resolving doubts and strengthening religious understanding. These jurisprudential foundations not only help in resolving doubts and clarifying religious issues, but also play a key role in creating unity and convergence among Muslims and answering new questions.