This study examines the Prophetic interpretation of the Holy Quran in interaction with the political exigencies of early Islam. The main question is how the Prophet Muhammad (PBUH) explained the verses in the Meccan and Medinan periods and what role this process played in the formation of the Islamic community. The research method is descriptive-analytical, based on historical, exegetical, and biographical sources. The findings indicate that in Mecca, the Prophetic interpretation was focused on critiquing the Jahili discourse and redefining values; emphasizing monotheism, rejecting the culture of pride, and condemning idolatry, which provided an intellectual foundation for resistance against the Quraysh order. The migration to Abyssinia also exemplified the connection between divine teachings and political-security necessities. In Medina, the Prophetic interpretation took on a state-building and institutional character; actions such as the Charter of Medina, brotherhood (Mu'akhah), establishment of the Prophet's Mosque, battles, and diplomatic relations demonstrated the translation of the verses into practical politics. The conclusion is that the difference between the Meccan and Medinan interpretations reflects the political structures of each period, and understanding this requires attention to the reciprocal link between revelation and social reality.