The purpose of this article is to analyze and study the semantic method and analyze and explain the role of this method in comparative interpretation. The method of this analytical-descriptive research, which attempts to clarify the role of the semantic method in approximate comparative interpretation by studying and analyzing the semantic method and also studying and analyzing comparative interpretation. According to the findings of this research, the semantic method (semantics) is a method that deals with the semantics and explanation of words; but its purpose is not simply to study the word, but rather to identify the semantic components and layers present in the relevant words in a specific text. In semantics, to achieve this goal, a variety of linguistic and non-linguistic methods indicating meaning are used, and a semantic spectrum is formed in which semantic relationships between different concepts are discovered. The semantic method can be used in the semantics of the Quran; but it can only be used as a method and tool. That is, the semantic method is used only as a necessary condition for interpreting and understanding the meanings of the Quranic concepts, not as a sufficient condition for reaching all the meanings of the Quran. The deep levels of the Quran and the different layers of Quranic concepts cannot be reached by the semantic method; with this method, only the layers and surfaces of Quranic concepts that are related to words can be understood.